At what blood lead level should chelation therapy be initiated?

Chelation therapy should be initiated when a child's blood lead level reaches or exceeds 45 micrograms per deciliter (ug/dL). This threshold is established based on research indicating that lead at such levels poses significant health risks, particularly to children. The primary goal of chelation therapy is to reduce the body burden of lead, inhibiting its toxic effects and preventing further health complications.

Levels above 45 ug/dL are associated with increased risk of cognitive impairment, developmental delays, and other serious health problems. Initiating treatment at this level helps to mitigate these risks and is consistent with guidelines provided by health organizations, which recommend monitoring and intervention at these critical lead levels.

Levels lower than 45 ug/dL do not typically warrant chelation therapy, as the potential risks of treatment may outweigh the benefits. Therefore, monitoring and interventions such as educational guidance about lead exposure sources might be recommended for those with lower concentrations.